Objetives.

This study has the following main objectives

Identify

Genetic markers of susceptibility and prognosis of COVID-19 infection

Identify

Local and systemic transcriptomic signatures that allow the accurate differential diagnosis of COVID-19 infection at different timepoints of infection, as well as establish prognostic markers for its natural history

Study

Differential expression patterns in different host samples

Identify

Soluble biomarkers related to the immune system that allow us to characterize and predict the immune response to COVID-19

Study

Proteomic patterns in different host samples and at different stages of the infection

Study

Pathogen genetic variability

GEN-COVID national and international integration.

At the national level

GEN-COVID will receive samples for genetic studies from the GENDRES network, the EPICAL national multicenter project (coordinated by Dr. Tagarro, Hospital 12 de Octubre) and from the GESNEO-COVID national multicenter project (coordinated by Dra. Marisa Navarro, Hospital Gregorio Marañón).

At the international level

GEN-COVID has cross-collaboration with other international consortiums related to COVID-19 and whose clinical coordination is carried out by the Galician Health Service (SERGAS) through the Pediatric Service of the University Clinical Hospital of Santiago, mainly through macro projects of European funding focused on the study of infections from the host's perceptive, specifically through the application of genomics, transcriptomics and proteomics to find diagnostic biomarkers related to infection.

  1. EUROPEAN PROJECT H2020 PERFORM (Grant Agreement 668303).

  2. EUROPEAN PROJECT H2020 DIAMONDS (Grant Agreement 848196).

  3. EUROPEAN PROJECT FP7 PREPARE (Grant Agreement 602525).

Publications & achievements.

A Strategy Targeting Monocyte-Macrophage Differentiation to Avoid Pulmonary Complications in SARS-Cov2 Infection

J Gómez-Rial 1, F Martinón-Torres 2.

Clin Immunol. 2020 Apr 23;216:108442.doi: 10.1016/j.clim.2020.108442. Online ahead of print.

See the study

Increased serum levels of sCD14 and sCD163 indicate a preponderantrole for monocytes in COVID-19 immunopathology

J Gómez Rial, MJ Curras Tuala, I Rivero Calle, A Gómez Carballa, M Cebey Lopez, C Rodriguez Tenreiro, A Dacosta Urbieta, N Rodriguez Nuñez, R Trastoy Pena, J Rodríguez García, A Salas F Martinon Torres and GENCOVID STUDY GROUP.

Submitted to peer-reviewjournal

Seroprevalence of SARS-CoV-2 among pediatric healthcare workers inSpain 

A Dacosta Urbieta, I Rivero Calle, J Pardo Seco, L Redondo Collazo, A Salas J Gómez Rial and F Martinón Torres

Submitted to peer-reviewjournal

COVID-19 therapy based on the role ofmonocyte-macrophage in sars-cov-2 cytokine storm pathogenesis

Jose Gómez Rial, Irene Rivero Calle, Antonio Salas and Federico Martinon-Torres

Submitted to peer-reviewjournal

A plausible hypothesis for myocardial injury with st-segment elevation observed in covid-19 patients

Gómez-Rial J, Salas A, Martinón-Torres F

Submitted to peer-reviewjournal

The impact of super-spreaders in COVID-19: mapping genome variation worldwide

Alberto Gómez-Carballa, Xabier Bello, Jacobo Pardo-Seco, Federico Martinón-Torres,

See the study

Research team.

Federico Martinón Torres

Principal investigator

Complejo Hospitalario Universitario de Santiago de Compostela

Antonio Salas Ellacuriaga  

Co-Principal Investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

José Gómez Rial

Sub-investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Irene Rivero Calle  

Sub-investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Lorenzo Redondo Collazo

Sub-investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Ana Isabel Dacosta Urbieta

Sub-investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Blanca Díaz Esteban

Sub-investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Montserrat López Franco  

Sub-investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Marta Lendoiro Fuentes

Sub-investigator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Susana Rey García

Sub-investigator (Pediatrics)

Complejo Hospitalario Universitario de Santiago de Compostela

Luis Valdés Cuadrado

Sub-investigator (Pneumology)

Complejo Hospitalario Universitario de Santiago de Compostela

Nuria Rodríguez Núñez

Sub-investigator (Pneumology)

Complejo Hospitalario Universitario de Santiago de Compostela

Vanessa Riveiro Blanco

Sub-investigator (Pneumology)

Complejo Hospitalario Universitario de Santiago de Compostela

Francisco Javier González Barcala  

Sub-investigator (Pneumology)

Complejo Hospitalario Universitario de Santiago de Compostela

Antonio Pose Reino

Sub-investigator (Internal Medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Antonio Antela López

Sub-investigator (Internal Medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Pablo Varela García

Sub-investigator (Internal Medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

María Jesús Domínguez Santalla

Sub-investigator (Internal Medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

María Pazo Núñez

Sub-investigator (Internal Medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Cristobal Galbán Rodríguez

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Ana López Lago

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Elena Giráldez Vázquez

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Carmen Rivero Velasco

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Eva Saborido Paz

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

José Luis García Allut

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Juan Fernández Villaverde

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Beatriz Lence Massa

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Carla Saito Villanueva

Sub-investigator (ICU)

Complejo Hospitalario Universitario de Santiago de Compostela

Manuel Taboada Muñiz

Sub-investigator (Anesthesia and Resuscitation)

Complejo Hospitalario Universitario de Santiago de Compostela

Julian Álvarez Escudero

Sub-investigator (Anesthesia and Resuscitation)

Complejo Hospitalario Universitario de Santiago de Compostela

Gloria Maria Prada Hervella

Sub-investigator (Anesthesia and Resuscitation)

Complejo Hospitalario Universitario de Santiago de Compostela

Mª Luisa Pérez del Molino Bernal

Sub-investigator (Microbiology)

Complejo Hospitalario Universitario de Santiago de Compostela

Gema Barbeito Castiñeiras

Sub-investigator (Microbiology)

Complejo Hospitalario Universitario de Santiago de Compostela

Daniel Navarro De la Cruz

Sub-investigator (Microbiology)

Complejo Hospitalario Universitario de Santiago de Compostela

José Javier Costa Alcalde

Sub-investigator (Microbiology)

Complejo Hospitalario Universitario de Santiago de Compostela

Antonio Aguilera Guirao

Sub-investigator (Microbiology)

Complejo Hospitalario Universitario de Santiago de Compostela

Amparo Coira Nieto

Sub-investigator (Microbiology)

Complejo Hospitalario Universitario de Santiago de Compostela

Juan Bautista Ortolá Devesa

Sub-investigator (Central Lab)

Complejo Hospitalario Universitario de Santiago de Compostela

Teresa QueiroVerdes

Sub-investigator (Preventive medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Hugo Pérez Freixo

Sub-investigator (Preventive medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Pablo Souto Sanmartín

Sub-investigator (Preventive medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Mónica Conde Pájaro

Nursing supervisor (Preventive medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Beatriz Guerra Liñares

Nurse (Preventive medicine)

Complejo Hospitalario Universitario de Santiago de Compostela

Pilar Leborans Iglesias

Nursing supervisor (Pediatrics)

Complejo Hospitalario Universitario de Santiago de Compostela

Eloína Núñez Masid

Manager of the Sanitary Area of Santiago de Compostela e Barbanza

Complejo Hospitalario Universitario de Santiago de Compostela

Manuel Portela Romero

Deputy Director of Pharmaceutical Delivery, Training, Teaching, Research and Innovation

Complejo Hospitalario Universitario de Santiago de Compostela

María Victoria Carral García

Director of Nursing Processes

Complejo Hospitalario Universitario de Santiago de Compostela

Lidia Piñeiro Rodríguez

Nurse (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Sara Rey Vázquez

Nurse (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

José Miguel Sadiki Orayyou

Nurse (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

María Soledad Vilas Iglesias

Nurse (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Sonia Serén Fernández

Nurse (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Luisa García Vicente

Nurse (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Alberto Gómez Carballa

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Jacobo Pardo Seco

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Xabier Bello Paderne

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

María José Currás Tuala

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Sara Pischedda

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Sandra Viz Lasheras

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Miriam Ben García

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Patricia Regueiro Casuso

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Miriam Cebey López

Laboratory staff (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Carmen Rodríguez-Tenreiro Sánchez

Research coordinator (GENVIP)

Complejo Hospitalario Universitario de Santiago de Compostela

Laura  Moreno

Sub Investigador (GENDRES)

H.Materno  Infantil / Hospital Virgen del Camino

Susana  Beatriz Reyes

Sub Investigador (GENDRES)

Hospital  Virgen de la Arrixaca de Murcia

Sonia  Sanchiz

Sub Investigador (GENDRES)

Hospital  Virgen de la Arrixaca de Murcia

Mari  Cruz León

Sub Investigador (GENDRES)

Hospital  Virgen de la Arrixaca de Murcia

Cristina  Calvo

Sub Investigador (GENDRES)

Hospital  La Paz

Carlos Grasa

Sub Investigador (GENDRES)

Hospital  La Paz

María  Jesús Cabero

Sub Investigador (GENDRES)

Hospital  Valdecilla

Marta  Pareja

Sub Investigador (GENDRES)

Hospital  General de Albacete

Pablo  Rojo

Sub Investigador (GENDRES)

Hospital  12 Octubre

Cristina  Epalza

Sub Investigador (GENDRES)

Hospital  12 Octubre

Patricia  Flores Pérez

Sub Investigador (GENDRES)

Hospital  Niño Jesús

Raquel  Jiménez

Sub Investigador (GENDRES)

Hospital  Niño Jesús

Mª  Yolanda Ruíz del Prado

Sub Investigador (GENDRES)

Hospital  San Pedro de La Rioja

David  Moreno

Sub Investigador (GENDRES)

Hospital  Carlos Haya

Beatríz  Carazo

Sub Investigador (GENDRES)

Hospital  Carlos Haya