This study has been approved by the Ethics Committee of Galicia by fast-track procedure on March 18, 2020
This study has the following main objectives
Genetic markers of susceptibility and prognosis of COVID-19 infection
Local and systemic transcriptomic signatures that allow the accurate differential diagnosis of COVID-19 infection at different timepoints of infection, as well as establish prognostic markers for its natural history
Differential expression patterns in different host samples
Soluble biomarkers related to the immune system that allow us to characterize and predict the immune response to COVID-19
Proteomic patterns in different host samples and at different stages of the infection
Pathogen genetic variability
Análisis multiómico de eventos Multi-omic analysis of vaccine adverse events (adversomics) and vaccine failure
GEN-COVID will receive samples for genetic studies from the GENDRES network, the EPICAL national multicenter project (coordinated by Dr. Tagarro, Hospital 12 de Octubre) and from the GESNEO-COVID national multicenter project (coordinated by Dra. Marisa Navarro, Hospital Gregorio Marañón).
We are working as part of the COVID-19 Host Genetics Initiative on high-throughput genotyping and massive parallell sequencing projects to investigate on the host genetics factors influencing susceptibility to COVID-19.
GEN-COVID has cross-collaboration with other international consortiums related to COVID-19 and whose clinical coordination is carried out by the Galician Health Service (SERGAS) through the Pediatric Service of the University Clinical Hospital of Santiago, mainly through macro projects of European funding focused on the study of infections from the host's perceptive, specifically through the application of genomics, transcriptomics and proteomics to find diagnostic biomarkers related to infection.
EUROPEAN PROJECT H2020 PERFORM (Grant Agreement 668303).
EUROPEAN PROJECT H2020 DIAMONDS (Grant Agreement 848196).
EUROPEAN PROJECT FP7 PREPARE (Grant Agreement 602525).
J Gómez-Rial 1, F Martinón-Torres 2
Clin Immunol. 2020 Jul;216:108442. doi: 10.1016/j.clim.2020.108442. Epub 2020 Apr 23.
PMID: 32335290 PMCID: PMC7194539 DOI: 10.1016/j.clim.2020.108442
Jose Gómez-Rial, Maria José Currás-Tuala, Irene Rivero-Calle, Alberto Gómez-Carballa, Miriam Cebey-López, Carmen Rodríguez-Tenreiro, Ana Dacosta-Urbieta, Carmen Rivero-Velasco, Nuria Rodríguez-Núñez, Rocio Trastoy-Pena, Javier Rodríguez-García, Antonio Salas, and Federico Martinón-Torres
Front Immunol. 2020 Sep 23;11:560381. doi: 10.3389/fimmu.2020.560381. eCollection 2020
PMID: 33072099 PMCID: PMC7538662 DOI: 10.3389/fimmu.2020.560381
A Dacosta Urbieta, I Rivero Calle, J Pardo Seco, L Redondo Collazo, A Salas J Gómez Rial and F Martinón Torres
Front Pediatr. 2020 Sep 11;8:547. doi: 10.3389/fped.2020.00547. eCollection 2020.
PMID: 33042908 PMCID: PMC7516980 DOI: 10.3389/fped.2020.00547
Gómez-Rial J, Rivero-Calle I, Salas A, Martinón-Torres F
Infect Drug Resist . 2020 Jul 22;13:2485-2493. doi: 10.2147/IDR.S258639. eCollection 2020
PMID: 32801787 PMCID: PMC7383015 DOI: 10.2147/IDR.S258639
Alberto Gomez-Carballa, Xabi Bello, Jacobo Pardo-Seco, Federico Martinon-Torres and Antonio Salas
Genome Res. 2020 Oct;30(10):1434-1448. doi: 10.1101/gr.266221.120. Epub 2020 Sep 2.
PMID: 32878977 PMCID: PMC7605265 (available on 2021-04-01) DOI: 10.1101/gr.266221.120
Alberto Gómez-Carballa, Xabier Bello, Jacobo Pardo-Seco, María Luisa Pérez Del Molino Federico Martinón-Torres, Antonio Salas
Zool Res. 2020 Nov 18;41(6):605-620. doi: 10.24272/j.issn.2095-8137.2020.217.
PMID: 32935498 PMCID: PMC7671907 DOI: 10.24272/j.issn.2095-8137.2020.217
Pardo-Seco J, Gómez-Carballa A, Bello X, Martinón-Torres F, Salas A.
Zool Res. 2021 Jan 18;42(1):87-93. doi: 10.24272/j.issn.2095-8137.2020.364.
PMID: 33410308.
Salas A, Bello X, Pardo-Seco J, Martinón-Torres F, Gómez-Carballa
A (2021) Superspreading: The engine of the SARS-CoV-2 pandemic. Science, eLetter;
Alberto Gómez-Carballa , Irene Rivero-Calle, Jacobo Pardo-Seco, José Gómez-Rial, Carmen Rivero-Velasco, Nuria Rodríguez-Núñez, Gema Barbeito-Castiñeiras, Hugo Pérez-Freixo, Miriam Cebey-López, Ruth Barral-Arca, Carmen Rodriguez-Tenreiro, Ana Dacosta-Urbieta, Xabier Bello, Sara Pischedda, María José Currás-Tuala, Sandra Viz-Lasheras, Federico Martinón-Torres, Antonio Salas, GEN-COVID study group
Environ Res. 2022 Feb 22;210:112890. doi: 10.1016/j.envres.2022.112890
PMID: 35202626 PMCID: PMC8861187 DOI: 10.1016/j.envres.2022.112890
GaIN Rescata-Covid_IN845D 2020/23 projects
Principal investigator
Complejo Hospitalario Universitario de Santiago de Compostela
Co-Principal Investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Pediatrics)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Pneumology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Pneumology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Pneumology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Pneumology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Internal Medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Internal Medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Internal Medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Internal Medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Internal Medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (ICU)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Anesthesia and Resuscitation)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Anesthesia and Resuscitation)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Anesthesia and Resuscitation)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Microbiology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Microbiology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Microbiology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Microbiology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Microbiology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Microbiology)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Central Lab)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Preventive medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Preventive medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub-investigator (Preventive medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Nursing supervisor (Preventive medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Nurse (Preventive medicine)
Complejo Hospitalario Universitario de Santiago de Compostela
Nursing supervisor (Pediatrics)
Complejo Hospitalario Universitario de Santiago de Compostela
Manager of the Sanitary Area of Santiago de Compostela e Barbanza
Complejo Hospitalario Universitario de Santiago de Compostela
Deputy Director of Pharmaceutical Delivery, Training, Teaching, Research and Innovation
Complejo Hospitalario Universitario de Santiago de Compostela
Director of Nursing Processes
Complejo Hospitalario Universitario de Santiago de Compostela
Nurse (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Nurse (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Nurse (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Nurse (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Nurse (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Nurse (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Laboratory staff (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Research coordinator (GENVIP)
Complejo Hospitalario Universitario de Santiago de Compostela
Sub Investigador (GENDRES)
H.Materno Infantil / Hospital Virgen del Camino
Sub Investigador (GENDRES)
Hospital Virgen de la Arrixaca de Murcia
Sub Investigador (GENDRES)
Hospital Virgen de la Arrixaca de Murcia
Sub Investigador (GENDRES)
Hospital Virgen de la Arrixaca de Murcia
Sub Investigador (GENDRES)
Hospital La Paz
Sub Investigador (GENDRES)
Hospital La Paz
Sub Investigador (GENDRES)
Hospital Valdecilla
Sub Investigador (GENDRES)
Hospital General de Albacete
Sub Investigador (GENDRES)
Hospital 12 Octubre
Sub Investigador (GENDRES)
Hospital 12 Octubre
Sub Investigador (GENDRES)
Hospital Niño Jesús
Sub Investigador (GENDRES)
Hospital Niño Jesús
Sub Investigador (GENDRES)
Hospital San Pedro de La Rioja
Sub Investigador (GENDRES)
Hospital Carlos Haya
Sub Investigador (GENDRES)
Hospital Carlos Haya
Evaluation of the influence of genetic factors on SARS-CoV-2 infection
Código de protocolo: GEN-COVID19
Aprobación por el CEIC de Galiciavía fast-track el 18 de marzo de 2020
Developed from the Clinical, Infectious and Translational Pediatrics of the Hospital Clínico Universitario of Santiago de Compostela, chosen as the best infectious service in Spain (“Best in Class” prize 2018, 2019 and 2020) and from the Genetics, Vaccines, Infections and Pediatrics group (GENVIP), the research international “Zendal” prize 2019 of the Institute of Healthcare Research from Santiago de Compostela.
COVID-19; parallel sequencing; NGS; exomes; whole-genome sequencing; gene expression; RNAseq; nanostring; proteomics.
